Headed by the Caritas Secretary, the Caritas Commission is the Socio-economic arm of the Diocese. Driven the Social Doctrines of the Catholic Church, the Diocese of Karonga believes that preaching the Gospel and attention to the socio-economic needs of the people go hand in hand.
The Diocese realizes that the socio-economic challenges of the people are also the challenges of the Body of Christ, the Church (Cf. Gaudium et Spes, 1). The current Caritas Secretary is Mr. Mwawi Shaba.

The Caritas Commission has four major desks/departments namely; Development Desk, Justice and Peace Desk, Health Desk and Education Desk.